Our discovery of the connection between persistent stress granules and neurodegenerative disease is one of the most promising developments today and could offer amazing new hope for patients and their families. This potential breakthrough is especially significant after years of disappointment in ALS and Alzheimer’s research.
The strength of our science is the result of a long commitment to neurodegenerative research, exacting standards and a fresh, out-of-the-box approach. We have been awarded four peer-reviewed grants and support from major pharmaceutical companies.
We have assembled an elite team of award-winning scientists and experienced drug developers to help ensure success in overcoming the challenge of ALS (amyotrophic lateral sclerosis, better known as Lou Gehrig’s disease), Alzheimer’s (AD) and other neurodegenerative diseases.
Although neurodegenerative drug development has historically been associated with some level of risk, our team has made great strides in mitigating this problem. We have established a proven genetic cause, a validated pathology, initial proof of concept and have assembled an experienced team to make it happen.
As the population ages, the incidence of neurodegenerative disease in the US will rise dramatically. Without any breakthroughs in treatment, it is estimated the number of people with Alzheimer’s disease will nearly triple by 2050. ALS is also predicted to increase by an astonishing 70% by 2040.
A diagnosis of ALS or Alzheimer’s disease leaves patients with few options. There are currently no approved treatments that can prevent, slow or reverse these devastating, progressive diseases.
ALS is caused by the loss of motor neurons in the brain. These neurons control muscle movement and eventually shut down one’s ability to walk, talk, swallow and finally breath. ALS progresses rapidly, killing over half the patients in only 3 years from the time of diagnosis. The only drug, approved almost two decades ago, extends survival by only 2-3 months.
Alzheimer’s disease presents with a gradual loss of memory and executive function—the ability for complex reasoning and decision making. Few other diseases create such fear— fear of getting it, fear of losing your identity and connection to loved ones, and fear of losing control of your life.
Both of these diseases place significant pressure on families and financial resources.
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